For more information, visit or new research raises the possibility of reversing the impacts of fibrosis and similar diseases that cause lung inflammation, which gradually damages lung tissue and makes internal organs less able to transfer oxygen to the blood. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. The study was supported by startup funds from CUMC and the New York Stem Cell Foundation.Ĭolumbia University Medical Center provides international leadership in basic, preclinical, and clinical research medical and health sciences education and patient care. The authors declare no other financial or other conflicts of interests. Green, and Jahar Bhattacharya (all at CUMC).Ĭolumbia University has filed for a patent relating to the generation of lung and airway epithelium from human pluripotent stem cells and uses thereof. Huang, Mohammad Naimul Islam, John O’Neill, Zheng Hu, Yong-Guang Yang, Ya-Wen Chen, Melanie Mumau, Michael D. The paper is titled, “Highly efficient generation of airway and lung epithelial cells from human pluripotent stem cells.” “I am excited about this collaboration with Hans Snoeck, integrating stem cell science with bioengineering in the search for new treatments for lung disease,” said Gordana Vunjak-Novakovic, PhD, co-author of the paper and Mikati Foundation Professor of Biomedical Engineering at Columbia’s Engineering School and professor of medical sciences at Columbia University College of Physicians and Surgeons. Snoeck is investigating this approach in collaboration with researchers in the Columbia University Department of Biomedical Engineering. In this way, rejection problems could be avoided.” Dr. “This would entail taking a lung from a donor removing all the lung cells, leaving only the lung scaffold and seeding the scaffold with new lung cells derived from the patient. “In the longer term, we hope to use this technology to make an autologous lung graft,” Dr. “Using this technology, researchers will finally be able to create laboratory models of IPF, study the disease at the molecular level, and screen drugs for possible treatments or cures.” “No one knows what causes the disease, and there’s no way to treat it,” says Dr. The findings have implications for the study of a number of lung diseases, including idiopathic pulmonary fibrosis (IPF), in which type 2 alveolar epithelial cells are thought to play a central role. Type 2 cells are important because they produce surfactant, a substance critical to maintain the lung alveoli, where gas exchange takes place they also participate in repair of the lung after injury and damage. The resultant cells were found to express markers of at least six types of lung and airway epithelial cells, particularly markers of type 2 alveolar epithelial cells. Snoeck and his colleagues found new factors that can complete the transformation of human ES or iPS cells into functional lung epithelial cells (cells that cover the lung surface).
Human iPS cells can then be stimulated to differentiate into specialized cells-offering researchers an alternative to human ES cells.)
Stem cell treatment lung disease skin#
(Human iPS cells closely resemble human ES cells but are generated from skin cells, by coaxing them into taking a developmental step backwards.
Snoeck’s 2011 discovery of a set of chemical factors that can turn human embryonic stem (ES) cells or human induced pluripotent stem (iPS) cells into anterior foregut endoderm-precursors of lung and airway cells. Although any clinical application is still many years away, we can begin thinking about making autologous lung transplants-that is, transplants that use a patient’s own skin cells to generate functional lung tissue.” This is important because lung transplants have a particularly poor prognosis. “Now, we are finally able to make lung and airway cells. “Researchers have had relative success in turning human stem cells into heart cells, pancreatic beta cells, intestinal cells, liver cells, and nerve cells, raising all sorts of possibilities for regenerative medicine,” said study leader Hans-Willem Snoeck, MD, PhD, professor of medicine (in microbiology & immunology) and affiliated with the Columbia Center for Translational Immunology and the Columbia Stem Cell Initiative.
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